MY DEAR FRIEND: I am extremely concerned at the return of your old asthmatic complaint, of which your letter from Cassel of the 28th July, N. S., in forms me. I believe it is chiefly owing to your own negligence; for, notwithstanding the season of the year, and the heat and agitation of traveling, I dare swear you have not taken one single dose of gentle, cooling physic, since that which I made you take at Bath. I hope you are now better, and in better hands. I mean in Dr. Hugo's at Hanover: he is certainly a very skillful physician, and therefore I desire that you will inform him most minutely of your own case, from your first attack in Carniola, to this last at Marpurgh; and not only follow his prescriptions exactly at present, but take his directions, with regard to the regimen that he would have you observe to prevent the returns of this complaint; and, in case of any returns, the immediate applications, whether external or internal, that he would have you make use of. Consider, it is very worth your while to submit at present to any course of medicine or diet, to any restraint or confinement, for a time, in order to get rid, once for all, of so troublesome and painful a distemper; the returns of which would equally break in upon your business or your pleasures. Notwithstanding all this, which is plain sense and reason, I much fear that, as soon as ever you are got out of your present distress, you will take no preventive care, by a proper course of medicines and regimen; but, like most people of your age, think it impossible that you ever should be ill again. However, if you will not be wise for your own sake, I desire you will be so for mine, and most scrupulously observe Dr. Hugo's present and future directions.