Эгоистичная митохондрия. Как сохранить здоровье и отодвинуть старость

Eichenlaub-Ritter U. Oocyte aging and its cellular basis. Int J Dev Biol. 2012; 56(10–12):841–52. doi:10.1387/ijdb.120141ue.

Grindler N. M., Moley K. H. Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems. Mol Hum Reprod. 2013 Aug; 19(8): 486–94. Epub 2013 Apr 23. doi:10.1093/molehr/gat026.

Kang E., et al. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016 Dec 8;540(7632):270–5. doi:10.1038/nature20592.

Latorre-Pellicer A., et al. Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature. 2016 Jul 28; 535(7613):561–5. Epub 2016 Jul 6. doi:10.1038/nature 18618.

Pang W., et al. Low expression of Mfn2 is associated with mitochondrial damage and apoptosis in the placental villi of early unexplained miscarriage. Placenta. 2013 Jul; 34(7):613–8. Epub 2013 Apr 17. doi:10.1016/j. placenta.2013.03.013.

Sato M., Sato K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science. 2011 Nov 25; 334(6059):1141–4. doi:10.1126/science.1210333.

Tillett T. Potential mechanism for PM10 effects on birth outcomes: in utero exposure linked to mitochondrial DNA damage. Environ Health Perspect. 2012 Sep; 120(9):A363. doi:10.1289 /ehp.120-a363b.

Zuccotti M., Redi C. A., Garagna S. Study an egg today to make an embryo tomorrow. Int J Dev Biol. 2012; 56(10–12):761–4. doi:10.1387/ ijdb.130027mz.

Глазные болезни

Banerjee D., et al. Mitochondrial genome analysis of primary open angle glaucoma patients. PLoS One. 2013 Aug 5; 8(8):e70760. doi:10.1371/ journal.pone.0070760.

Blasiak J., et al. Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration. Int J Mol Sci. 2013 Feb;14(2):2996–3010. Epub 2013 Jan 31. doi:10.3390 /ijms14022996.

Chen S. D., Wang L., Zhang X. L. Neuroprotection in glaucoma: present and future. Chin Med J (Engl). 2013 Apr; 126(8):1567–77. doi:10.3760/ cma.j.issn.0366–6999.20123565.

Ghiso J. A., et al. Alzheimer’s disease and glaucoma: mechanistic similarities and differences. J Glaucoma. 2013 Jun — Jul; 22 Suppl 5:S36–S38. doi:10.1097/IJG.0b013e3182934af6.

Izzotti A., et al. Mitochondrial damage in the trabecular meshwork of patients with glaucoma. Arch Ophthalmol. 2010 Jun; 128(6):724–30. doi:10.1001/archophthalmol.2010.87.

Lee V., et al. Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function. Neurobiol Aging. 2012 Oct; 33(10):2382–9. Epub 2012 Jan 2. doi:10.1016/j.neurobiolag-ing.2011.

Wang M. Y., Sadun A. A. Drug-related mitochondrial optic neuropathies. J Neuroophthalmol. 2013 Jun;33(2):172–8. doi:10.1097/ WNO.0b013e3182901969.

Стволовым клеткам нужны здоровые митохондрии

Conboy I. M., Rando T. A. Aging, stem cells and tissue regeneration: lessons from muscle. Cell Cycle. 2005 Mar; 4(3):407–10. doi:10.4161/cc.4.3.1518. Flynn J. M., Melov S. SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:4–12. Epub May 29 2013. doi:10.1016/j.freeradbiomed.2013.05.027.

Garcia M. L., Fernandez A., Solas M. T. Mitochondria, motor neurons and aging. J Neurol Sci. 2013 Jul 15. Epub 2013 Apr 26. doi:10.1016/j. jns.2013.03.019.

Hosoe K., et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb; 47(1):19–28. doi:10.1016/j. yrtph.2006.07.001.

Katajisto P., et al. Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science. 2015 Apr 17; 348(6232):340–3. Epub 2015 Apr 2. doi:10.1126/sci-ence.1260384.

Sahin E., DePinho R. A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010 Mar 25;464(7288):520–8. doi:0.1038/nature08982.

Онкологические заболевания: осознание причин приближает к их устранению

Adams J. S., Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998 Aug 28; 281(5318):1322–6.

Brown J. M. Tumor microenvironment and the response to anticancer therapy. Cancer Biol Ther. 2002 Sep — Oct; 1(5):453–8. doi:10.4161/ cbt.1.5.157.

Bui T., Thompson C. B. Cancer’s sweet tooth. Cancer Cell. 2006 Jun; 9(6):419–20. doi:10.1016 /j.ccr.2006.05.012.