Эгоистичная митохондрия. Как сохранить здоровье и отодвинуть старость

Carrière A., et al. Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure. Diabetes. 2014 Oct; 63(10):3253–65. Epub 2014 May 1. doi:10.2337/db13-1885. Castello L, et al. Calorie restriction protects against age-related rat aorta sclerosis. FASEB J. 2005 Nov; 19(13):1863–5. Epub 2005 Sep 8. doi:10.1096/ fj.04-2864fje. Cohen HY, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004 Jul 16; 305(5682):390–2. doi:10.1126/science.1099196. Colman RJ, et al. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 2014 Apr 1; 5:3557. doi:10.1038/ncomms4557.

Estrada N. M., Isokawa M. Metabolic demand stimulates CREB signaling in the limbic cortex: implication for the induction of hippocampal synaptic plasticity by intrinsic stimulus for survival. Front Syst Neurosci. 2009 Jun 9; 3:5. doi:10.3389/neuro.06.005.2009.

Guarente L., Picard F. Calorie restriction — the SIR2 connection. Cell. 2005 Feb 25; 120(4): 473–82. doi:10.1016/j.cell.2005.01.029.

Hasselbalch S. G., et al. Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab. 1994 Jan; 14(1):125–31. doi:10.1038/ jcbfm.1994.17.

Ivanova D. G., Yankova T. M. The free radical theory of aging in search of a strategy for increasing life span. Folia Med (Plovdiv). 2013 Jan — Mar; 55(1):33–41. doi:10.2478/folmed-2013-0003.

Jarrett S. G., et al. The ketogenic diet increases mitochondrial glutathione levels. J Neurochem. 2008 Aug; 106(3):1044–51. doi:10.1111/j.1471–4159.2008.05460.x. Epub 2008 May 5.

Jung K. J., et al. The redox-sensitive DNA binding sites responsible for age-related downregulation of SMP30 by ERK pathway and reversal by calorie restriction. Antioxid Redox Signal. 2006 Mar — Apr;8(3–4):671–80. doi:10.1089/ars.2006.8.671.

Kashiwaya Y., et al. D-b-hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease. Proc Natl Acad Sci USA. 2000 May 9; 97(10):5440–4. doi:10.1073/pnas.97.10.5440.

Kodde I. F., et al. Metabolic and genetic regulation of cardiac energy substrate preference. Comp Biochem Physiol A Mol Integr Physiol. 2007 Jan; 146(1):26–39. Epub 2006 Oct 3. doi:10.1016/j.cbpa.2006.09.014.

Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev. 1999 Nov — Dec;15(6):412–26. doi:10.1002 /(SICI)1520-7560(199911/12)15:6<412::AID-DMRR72>3.0.CO;2–8.

Lim E. L., et al. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia. 2011 Oct;54(10):2506–14. Epub 2011 Jun 9. doi:10.1007/ s00125-011-2204-7.

Lin S. J, et al. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004 Jan 1; 18(1):12–6. doi:10.1101/gad.1164804. Mattson M. P., Chan S. L., Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev. 2002 Jul; 82(3):637–72. doi:10.1152/physrev.00004.2002.

McInnes N., et al. Piloting a remission strategy in type 2 diabetes: results of a randomized controlled trial. J Clin Endocrinol Metab. 2017 May 1; 102(5):1596–1605. Epub 2017 Mar 15. doi:10.1210/jc.2016–3373.

Mercken E. M., et al. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell. 2013 Aug; 12(4):645–51. Epub 2013 Apr 20. doi:10.1111/acel.12088.

Picard F., et al. Sirt 1 promotes fat mobilization in white adipocytes by repressing PPARgamma. Nature. 2004 Jun 17; 429(6993):771–6. doi:10.1038/ nature02583.

Prins M. L. Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab. 2008 Jan; 28(1):1–16. Epub 2007 Aug 8. doi:10.1038/sj.jcbfm.9600543.

Revollo J. R., Grimm A. A., Imai S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem. 2004 Dec 3; 279(49):50754–63. doi:10.1074/ jbc.M408388200.

Rose G., et al. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol. 2003 Oct; 38(10):1065–70. doi:10.1016/S0531-5565(03)00209-2.

Sato K., et al. Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J. 1995 May; 9(8):651–8.

Scheibye-Knudsen M, et al. A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. Cell Metab. 2014 Nov 4; 20(5):840–55. Epub 2014 Nov 4. doi:10.1016/j.cmet.2014.10.005.