Грязные гены. «Большая стирка» для вашей ДНК. Как изменить свою наследственность

105. BH4 given to support NOS3: Vásquez-Vivar, J. et al. “Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants,” Arteriosclerosis, Thrombosis, and Vascular Biology, 1 October 2002, https://www.ncbi.nlm.nih.gov/pubmed/12377745.

106. Effectiveness of BH4 given to support NOS3: Mäki-Petäjä, KM. et al. “Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis,” Journal of the American Heart Association, 19 February 2016, https://www.ncbi.nlm.nih.gov/pubmed/26896473.

107. How the body uses arginine: Förstermann, Ulrich, Sessa, William C. “Nitric oxide synthases: regulation and function,” European Heart Journal, April 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345541/.

108. Folic acid increases, level of BH4 decreases: Smith, Desirée E.C. et al. “Folic acid, a double-edged sword? Influence of folic acid on intracellular folate and dihydrofolate reductase activity,” Semantic Scholar, Accessed January 2017, https://pdfs.semanticscholar.org/d934/683d6176b469ff636c4e202b8f99f6bb7217.pdf

109. Sleep apnea and NOS3: Badran, Mohammad et al. “Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals,” Sleep Disorders, 2015, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438195/.

110. Elevated levels of homocysteine leads to increased levels of ADMA: Selley, ML. “Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer’s disease,” Neurobiology of Aging, November 2003, https://www.ncbi.nlm.nih.gov/pubmed/12928048.

111. High ADMA levels found in dementia: Selley, ML. “Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer’s disease,” Neurobiology of Aging, November 2003, https://www.ncbi.nlm.nih.gov/pubmed/12928048.

112. Heart disease related death in dementia patients: Brunnström, HR., Englund, EM. “Cause of death in patients with dementia disorders,” European Journal of Neurology, April 2009, https://www.ncbi.nlm.nih.gov/pubmed/19170740.

113. BH4 has no benefit if oxidative stress is present: Kirsch, Michael et al. “The Autoxidation of Tetrahydrobiopterin Revisited,” The Journal of Biological Chemistry, 24 April 2003, http://www.jbc.org/content/278/27/24481.abstract.

114. BH4 has no benefit if oxidative stress is present: Vásquez-Vivar, Jeannette. “Tetrahydrobiopterin, Superoxide and Vascular Dysfunction,” Free Radical Biology and Medicine, 21 July 2009, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852262/.

11: PEMT: клеточные мембраны и печень

115. Role of phosphatidylcholine: Vance, Dennis E., Li, Zhaoyu, Jacobs, Rene L. “Hepatic Phosphatidylethanolamine N-Methyltransferase, Unexpected Roles in Animal Biochemistry and Physiology,” The Journal of Biological Chemistry, 16 November 2007, http://www.jbc.org/content/282/46/33237.full.pdf.

116. Role of phosphatidylcholine: “Choline,” Oregon State University Linus Pauling Institute Micronutrient Information Center, Accessed April 2017, http://lpi.oregonstate.edu/mic/other-nutrients/choline.

117. Phosphatidylcholine helps move triglycerides: “Choline,” Oregon State University Linus Pauling Institute Micronutrient Information Center, Accessed April 2017, http://lpi.oregonstate.edu/mic/other-nutrients/choline.

12. Курс «Замочить и оттереть». Первые две недели

118. Choline: An Essential Nutrient for Public Health: Steven H. Zeisel, M.D., Ph.D.; Kerry-Anda Costa, Ph.P, Nutr. Rev., November 2009, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/

119. Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD), Faseb J., 19 August 2005, http://www.ncbi.nlm.nih.gov/pubmed/16051693

120. Choline and risk of neural tube defects in a folate-fortified population, Epidemiology, September 2009, http://www.ncbi.nlm.nih.gov/pubmed/19593156