Танец жизни. Новая наука о том, как клетка становится человеком

[8] D. ten Berge, W. Koole, C. Fuerer, M. Fish, E. Eroglu, R. Nusse. Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies. Cell Stem Cell 3. No. 5 (2008): 508-518. Doi: 10.1016/j. stem.2008.09.013.

[9] I. Bedzhov, M. Zernicka-Goetz. Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation. Cell 156 (2014): 1032-1044. Doi: 10.1016/j.cell.2014.01.023.

[10] Ibid.

[11] Susanne C. van den Brink, Peter Baillie-Johnson, Tina Balayo, An-na-Katerina Fladjantonakis, Sonja Nowotschin, David A. Turner, Alfonso Martinez Arias. Symmetry Breaking, Germ Layer Specification and Axial Organisation in Aggregates of Mouse Embryonic Stem Cells. Development 141 (2014): 4231—4242. Doi:10.1242/dev.l 13001.

[12] D. ten Berge, W. Koole, C. Fuerer, M. Fish, E. Eroglu, R. Nusse. Wnt Signaling Mediates Self-Organization and Axis Formation in Embry oid Bodies. Cell Stem Cell 3. No. 5 (2008): 508-518. Doi: 10.1016/j. stem.2008.09.013.

[13] R. S. Beddington, P. Rashbass, V. Wilson. Brachyury — A Gene Affecting Mouse Gastrulation and Early Organogenesis. Development Supplement (1992): 157-165.

[14] S. E. Flarrison, B. Sozen, N. Christodoulou, C. Kyprianou, M. Zernicka-Goetz. Assembly of Embryonic and Extraembryonic Stem Cells to Mimic Embryogenesis In Vitro. Science 356 (2017): eaall810. Doi: 10.1126/science.aall810.

[15] N. C. Rivron, J. Frias-Aldeguer, E. J. Vrij, J.-C. Boisset, J. Korving, J. Vivid, R. K. Truckenmiiller, A. van Oudenaarden, C. A. van Blit-terswijk, N. Geijsen. Blastocyst-Like Structures Generated Solely from Stem Cells. Nature 557 (2018): 106-111. Doi: 10.1038/s41586-018-0051-0.

[16] B. Sozen, G. Amadei, A. Cox, R. Wang, E. Na, S. Czukiewska, L. Chappell, T. Voet, G. Michel, N. Jing, D. M. Glover, M. Zer-nicka-Goetz. Self-Assembly of Embryonic and Two Extra-Embryonic Stem Cell Types into Gastrulating Embryo-Like Structures. Nature Cell Biology 20 (2018): 979-989. Doi: 10.1038/s41556-018-0147-7.

[17] Martin A. N owak. Five Rules for the Evolution of Cooperation. Science 314(2006): 1560-1563. Doi: 10.1126/science.l 133755.

[18] Why Mouse Matters. National Human Genome Research Institute, accessed April 5, 2019. URL: www.genome.gov/10001345/impor-tance-of-mouse-genome/.

[19] Nicolas Rivron, Martin Pera, Janet Rossant, Alfonso Arias, Magdalena Zernicka-Goetz, Jianping Fu, Susanne Van den Brink, Annelien Bredenoord, Wybo Dondorp, Guido de Wert, Insoo Hyun, Megan Munsie, Rosario Isasi. Debate Ethics of Embryo Models from Stem Cells. Nature 564 (2018): 183-185. Doi: 10.1038/d41586-018-07663-9.

[20] I. Martyn, T. Y. Kanno, A. Ruzo, E. D. Siggia, A. H. Brivanlou. Self-Organization of a Human Organizer by Combined Wnt and Nodal Signalling. Nature 558 (2018): 132-135. Doi: 10.1038/s41586-018-0150-y.

[21] John Aach, Jeantine Lunshof, Eswar Iyer, George M. Church. Addressing the Ethical Issues Raised by Synthetic Human Entities with Embryo-Like Features. eLife 6 (2017): e20674. URL: https:// elifesciences.org/articles/20674, doi: 10.7554/eLife.20674.

[22] H. C. Ott, T. S. Matthiesen, S.-K. Goh, L. D. Black, S. M. Kren, T. I. Netoff, D. A. Taylor. Perfusion-Decellularized Matrix: Using Nature’s Platform to Engineer a Bioartificial Heart. Nature Medicine 14 (2008): 213-221. Doi:10.1038/nml684.

[23] Rivron et al. Debate Ethics of Embryo Models, 183—185.

Глава 10. Новая эра синтетической биологии

[1] 3D Atlas of Human Embryology, Carnegie Stage 7, accessed April 5, 2019. URL:3D Atlas of Human Embryology, Carnegie Stage 23, accessed April 5, 2019. URL:nl/3 DAtlas_CS23-9226-v2016-03.pdf; 3D Atlas of Human Embryology, accessed April 5, 2019. URL: www.3dembryoatlas.com/.

[2] В. S. de Ваккег, К. Н. de Jong, J. Hagoort, К. de Bree, С. T. Besselink, F. E. C. de Kanter, T. Veldhuis, B. Bais, R. Schildmeijer, J. M. Rui-jter, R. J. Oostra, V. M. Christoffels, A. F. Moorman. An Interactive Three-Dimensional Digital Atlas and Quantitative Database of Human Development. Science 354 (2016): aag0053. Doi:10.1126/science. aag0053.

[3] D. A. Jackson, R. H. Symons, R Berg. Biochemical Methodfor Inserting New Genetic Information into DNA of Simian Virus 40: Circular SV40 DNA Molecules Containing Lambda Phage Genes and the Galactose Орегон of Escherichia coli. Proceedings of the N ational Academy 69. No. 10 (1972): 2904-2909.

[4] CAR T Cells: Engineering Patients’ Immune Cells to Treat Their Cancers. National Cancer Institute, accessed April 5,2019. URL: www.cancer. gov/about-cancer/treatment/research/car-t-cells.

[5] M. Saitou, H. Miyauchi. Gametogenesisfrom Pluripotent Stem Cells. Cell Stem Cell 18 (2016): 721-735. Doi:10.1016/j.stem.2016.05.001.

[6] O. Hikabe, N. Hamazaki, G. Nagamatsu, Y. Obata, Y. Flirao, N. Hamada, S. Shimamoto, T. Imamura, K. Nakashima, M. Saitou, K. Hayashi. Reconstitution In Vitro of the Entire Cycle of the Mouse Female Germ Line. Nature 539 (2016): 299—303. Doi:10.1038/na-ture20!04.