В поисках памяти: Возникновение новой науки о человеческой психике

Результаты исследований приобретенного страха, указывающие на роль CREB-репрессора в подавлении долговременной памяти, а CREB-активатора – в ее усилении, опубликованы в статьях: J. C. P. Yin, J. S. Wallach, M. Del Vecchio, E. L. Wilder, H. Zhuo, W. G. Quinn & T. Tully, Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila, Cell 79 (1994): 49–58; J. C. P. Yin, M. Del Vecchio, H. Zhou & T. Tully, CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81 (1995): 107–115.

Данные о работе CREB-белков у пчел приведены в статье: D. Eisenhardt, A. Friedrich, N. Stollhoff, U. Miiller, H. Kress & R. Menzel, The AmCREB gene is an ortholog of the mammalian CREB / CREM family of transcription factors and encodes several splice variants in the honeybee brain, Insect Molecular Biol. 12 (2003): 373–382.

Данные о роли CREB-белков в приобретенном страхе у мышей приведены в статьях: P. W. Frankland, S. A. Josselyn, S. G. Anagnostaras et al., Consolidation of CS and US representations in associative fear conditioning, Hippocampus 14 (2004): 557–569 и S. Kida, S. A. Josselyn, S. P. de Ortiz et al., CREB required for the stability of new and reactivated fear memories, Nature Neurosci. 5 (2002): 348–355.

Данные о роли CREB-белков в обучении у человека приведены в статьях: J. M. Alarcon, G. Malleret, K. Touzani, S. Vronskaya, S. Ishii, E. R. Kandel & A. Barco, Chromatin acetylation, memory, and LTP are impaired in CBP+ /– mice: A model for the cognitive deficit in Rubinstein-Taybi Syndrome and its amelioration, Neuron 42 (2004): 947–959.

Другие сведения, приведенные в этой главе, почерпнуты из следующих источников:

Bailey, C. H., P. Montarolo, M. Chen, E. R. Kandel & S. Schacher. Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia. Neuron 9 (1992): 749–758.

Bartsch, D., A. Casadio, K. A. Karl, P. Serodio & E. R. Kandel. CREB-1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95 (1998): 211–223.

Bartsch, D., M. Ghirardi, A. Casadio, M. Giustetto, K. A. Karl, H. Zhu & E. R. Kandel. Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB-1 and CREB-2. Cell 103 (2000): 595–608.

Casadio, A., K. C. Martin, M. Giustetto, H. Zhu, M. Chen, D. Bartsch, C. H. Bailey & E. R. Kandel. A transient neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99 (1999): 221–237.

Chain, D. G., A. Casadio, S. Schacher, A. N. Hegde, M. Valbrun, N. Yamamoto, A. L. Goldberg, D. Bartsch, E. R. Kandel & J. H. Schwartz. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22 (1999): 147–156.

Dale, N. & E. R. Kandel. L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons, Proc. Natl. Acad. Sci. USA 90 (1993): 7163–7167.

Glanzman, D. L., E. R. Kandel & S. Schacher. Target-dependent structural changes accompanying long-term synaptic facilitation in Aplysia neurons. Science 249 (1990): 799–802.