Эффект теломер: революционный подход к более молодой, здоровой и долгой жизни

8. Brennan, T. A., et al., “Mouse Models of Telomere Dysfunction Phenocopy Skeletal Changes Found in Human Age‑Related Osteoporosis,” Disease Models and Mechanisms 7, no. 5 (May 2014): 583–592, doi:10.1242/dmm.014928.

9. Inomata, K., et al., “Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation,” Cell 137, no. 6 (June 12, 2009): 1088–1099, doi:10.1016/j.cell.2009.03.037.

10. Jaskelioff, M., et al., “Telomerase Reactivation Reverses Tissue Degeneration in Aged Telomerase‑Deficient Mice,” Nature 469, no. 7328 (January 6, 2011): 102–106, doi:10.1038/nature09603.

11. Panhard, S., I. Lozano, and G. Loussouam, “Greying of the Human Hair: A Worldwide Survey, Revisiting the ‘50’ Rule of Thumb,” British Journal of Dermatology 167, no. 4 (October 2012): 865–873, doi:10.1111/j.1365‑2133.2012.11095.x.

12. Christensen, K., et al., “Perceived Age as Clinically Useful Biomarker of Ageing: Cohort Study,” BMJ 339 (December 2009): b5262.

13. Noordam, R., et al., “Cortisol Serum Levels in Familial Longevity and Perceived Age: The Leiden Longevity Study,” Psychoneuroendocrinology 37, no. 10 (October 2012): 1669–1675; Noordam, R., et al., “High Serum Glucose Levels Are Associated with a Higher Perceived Age,” Age (Dordrecht, Netherlands) 35, no. 1 (February 2013): 189–195, doi:10.1007/s11357‑011‑9339‑9; and Kido, M., et al., “Perceived Age of Facial Features Is a Significant Diagnosis Criterion for Age‑Related Carotid Atherosclerosis in Japanese Subjects: J‑SHIPP Study,” Geriatrics and Gerontology International 12, no. 4 (October 2012): 733–740, doi:10.1111/j.1447‑0594.2011.00824.x.

14. Codd, V., et al., “Identification of Seven Loci Affecting Mean Telomere Length and Their Association with Disease,” Nature Genetics 45, no. 4 (April 2013): 422–427, doi:10.1038/ng.2528.

15. Haycock, P. C., et al., “Leucocyte Telomere Length and Risk of Cardiovascular Disease: Systematic Review and Meta‑analysis,” BMJ 349 (July 8, 2014): g4227, doi:10.1136/bmj.g4227.

16. Yaffe, K., et al., “Telomere Length and Cognitive Function in Community‑Dwelling Elders: Findings from the Health ABC Study,” Neurobiology of Aging 32, no. 11 (November 2011): 2055–2060, doi:10.1016/j.neurobiolaging.2009.12.006.

17. Cohen‑Manheim, I., et al., “Increased Attrition of Leukocyte Telomere Length in Young Adults Is Associated with Poorer Cognitive Function in Midlife,” European Journal of Epidemiology 31, no. 2 (February 2016), doi:10.1007/s10654‑015‑0051‑4.

18. King, K. S., et al., “Effect of Leukocyte Telomere Length on Total and Regional Brain Volumes in a Large Population‑Based Cohort,” JAMA Neurology 71, no. 10 (October 2014): 1247–1254, doi:10.1001/jamaneurol.2014.1926.

19. Honig, L. S., et al., “Shorter Telomeres Are Associated with Mortality in Those with APOE Epsilon4 and Dementia,” Annals of Neurology 60, no. 2 (August 2006): 181–187, doi:10.1002/ana.20894.

20. Zhan, Y., et al., “Telomere Length Shortening and Alzheimer Disease – A Mendelian Randomization Study,” JAMA Neurology 72, no. 10 (October 2015): 1202–1203, doi:10.1001/jamaneurol.2015.1513.

21. If you would like, you can contribute to studies on brain aging and disease without having to get your brain scanned, or even show up in person. Dr. Mike Weiner, a noted researcher at UCSF who leads the largest cohort study of Alzheimer’s disease worldwide, developed the online Brain Health Registry to help speed up recruitment for clinical trials and research studies. By joining the Brain Health Registry you answer questionnaires and take online cognitive tests. We are helping him study the effects of stress on brain aging. You can find the registry at http://www.brainhealthregistry.org/

22. Ward, R. A., “How Old Am I? Perceived Age in Middle and Later Life,” International Journal of Aging and Human Development 71, no. 3 (2010): 167–184.

23. Ibid.

24. Levy, B., “Stereotype Embodiment: A Psychosocial Approach to Aging,” Current Directions in Psychological Science 18, vol. 6 (December 1, 2009): 332–336.

25. Levy, B. R., et al., “Association Between Positive Age Stereotypes and Recovery from Disability in Older Persons,” JAMA 308, no. 19 (November 21, 2012): 1972–1973, doi:10.1001/jama.2012.14541; Levy, B. R., A. B. Zonderman, M. D. Slade, and L. Ferrucci, “Age Stereotypes Held Earlier in Life Predict Cardiovascular Events in Later Life,” Psychological Science 20, no. 3 (March 2009): 296–298, doi:10.1111/j.1467‑9280.2009.02298.x.