Грязные гены. «Большая стирка» для вашей ДНК. Как изменить свою наследственность

13. Methylation helps efficiently burn fuel: Wenyi, XU et al. “Epigenetics and Cellular Metabolism,” Genetics and Epigenetics, 25 September 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038610/.

14. Methylation helps efficiently burn fuel: Donohoe, Dallas R., Bultman, Scott J. “Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression,” J Cell Physiol, September 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338882/.

15. 2.5 million that die every second: “How many cells do we have in our body?” UCSB Science Line, 2015, http://scienceline.ucsb.edu/getkey.php?key=3926.

16. Pain, fatigue, inflammation, and fatty liver caused by lack of new cells: Sanders, Lisa M., Zeisel, Stephen H. “Choline,” Nutr Today, 2007, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518394/.

17. Neural tube defects and congenital heart defects are a methylation issue: Blom, Henk J. et al. “Neural tube defects and folate: case far from closed,” Nature Reviews Neuroscience, September 2006, http://pubmedcentralcanada.ca/pmcc/articles/PMC2970514/.

18. Neural tube defects and congenital heart defects are a methylation issue: Imbard, Apolline, Benoist, Jean-François, Blom, Henk J. “Neural Tube Defects, Folic Acid and Methylation,” International Journal of Environmental Research and Public Health, 17 September 2013, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799525/.

19. Nausea, vomiting, and gallbladder pains, frequently caused by poor methylation: Jarnfelt-Samsioe A. “Nausea and vomiting in pregnancy: a review,” Obstetrical & Gynecological Survey, July 1987, https://www.ncbi.nlm.nih.gov/pubmed/3614796.

20. Gallbladder issues a big pregnancy issue: Pusi, Thomas, Beuers, Ulrich. “Intrahepatic cholestasis of pregnancy,” Orphanet Journal of Rare Disease, 29 May 2007, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891276/.

21. Methylation produces creatine: Bronsan, JT, Da Silva, RP, Bronsan, ME. “The metabolic burden of creatine synthesis,” Amino Acids, May 2011, https://www.ncbi.nlm.nih.gov/pubmed/21387089.

22. Poor methylation lead to muscular aches and pains: Onodi, Laszlo et al. “Creatine Treatment to Relieve Muscle Pain Caused by Thyroxine Replacement Therapy,” Pain Medicine, 12 April 2012, https://academic.oup.com/painmedicine/article-lookup/doi/10.1111/j.1526-4637.2012.01354.x.

23. Cardiovascular issues: Zhong, Jia, Agha, Golareh, Baccarelli Andrea A. “The Role of DNA Methylation in Cardiovascular Risk and Disease,” Circulation Research, 8 January 2016, http://circres.ahajournals.org/content/118/1/119.

24. To clear harmful chemicals and excess hormones, you need to methylate properly: Dawling S. et al. “Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wildtype and variant COMT isoforms,” Cancer Research, 15 September 2001, https://www.ncbi.nlm.nih.gov/pubmed/11559542.

25. Methylation affects your ability to produce glutathione: Prudova, Anna et al. “S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity,” Proceedings of the National Academy of Sciences of the United States of America, 9 March 2006, http://www.pnas.org/content/103/17/6489.full.

26. Methylation helps your immune system: Lei W. et al. “Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis,” Scandinavian Journal of Rheumatology, 2009, https://www.ncbi.nlm.nih.gov/pubmed/19444718.

27. Methylation helps prevent DNA errors when new cells are built: Bluont BC et al. “Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage,” Proceedings of the National Academy of Sciences of the United States of America, 1 April 1997, https://www.ncbi.nlm.nih.gov/pubmed/9096386.