Почему тело дает сбой. Как ежедневные привычки могут незаметно нас убивать

последующим накоплением в мозге тау-белков и амилоидов: Robert A. Stern et al., “Tau Positron-Emission Tomography in Former National Football League Players”, New England Journal of Medicine 380, no. 18 (May 2, 2019); Thor D. Stein et al., “Beta-Amyloid Deposition in Chronic Traumatic Encephalopathy”, Acta Neuropathologica 130, no. 1 (July 1, 2015).

связывают скрытое воспаление как с нейродегенеративными, так и с психическими проблемами: Megan E. Renna et al., “The Association between Anxiety, Traumatic Stress, and Obsessive-Compulsive Disorders and Chronic Inflammation: A Systematic Review and Meta-Analysis”, Depression & Anxiety 35, no. 11 (2018); Heeok Hong, Byung Sun Kim, and Heh-In Im, “Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders”, International Neurourology Journal 20, Suppl. 1 (2016).

скандальную работу: R. S. Smith, “The Macrophage Theory of Depression”, Medical Hypotheses 35, no. 4 (Aug. 1991).

способствуя таким проблемам, как депрессия: Bullmore, The Inflamed Mind; Beurel, Toups, and Nemeroff, “Bidirectional Relationship of Depression and Inflammation”; Chieh-Hsin Lee and Fabrizio Giuliani, “The Role of Inflammation in Depression and Fatigue”, Review, Frontiers in Immunology 10, no. 1696 (July 19, 2019).

в одном масштабном исследовании 2013 года: Marie Kim Wium-Andersen et al., “Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73,131 Individuals”, JAMA Psychiatry 70, no. 2 (2013).

оказывать прямое влияние на мозг и настроение: Neil A. Harrison et al., “Inflammation Causes Mood Changes through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity”, Biological Psychiatry 66, no. 5 (Sept. 1, 2009); Thomas E. Kraynak et al., “Functional Neuroanatomy of Peripheral Inflammatory Physiology: A Meta-Analysis of Human Neuroimaging Studies”, Neuroscience and Biobehavioral Reviews 94 (Nov. 2018).

дисрегуляция реакций как врожденного, так и адаптивного иммунитета: Eléonore Beurel, Marisa Toups, and Charles B. Nemeroff, “The Bidirectional Relationship of Depression and Inflammation: Double Trouble”, Neuron 107, no. 2 (July 22, 2020); George M. Slavich and Michael R. Irwin, “From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression”, Psychological Bulletin 140, no. 3 (May 2014).

Даже воспаления от вакцинации: Harrison et al., “Inflammation Causes Mood Changes”. the most common causes of death: David S. Jones, Scott H. Podolsky, and Jeremy A. Greene, “The Burden of Disease and the Changing Task of Medicine”, New England Journal of Medicine 366, no. 25 (June 21, 2012).

под новыми именами и фамилиями: Rehan P. Visser, “Fernando Pessoa’s Art of Living: Ironic Multiples, Multiple Ironies”, The Philosophical Forum 50, no. 4 (Dec. 1, 2019).

написал он на смертном одре в больнице Сан-Луиса: Carmela Ciuraru, Nom De Plume: A (Secret) History of Pseudonyms (New York: HarperCollins, 2011).

Глава 7. Разрешение

были одними из первых лекарств: Nicolâas G. Bazâan, Jack H. Botting, and John R. Vane, New Targets in Inflammation: Inhibitors of Cox‑2 or Adhesion Molecules (Dordrecht: Springer Netherlands, 1996); J. R. Vane and R. M. Botting, “The History of Anti-Inflammatory Drugs and Their Mechanism of Action”, in New Targets in Inflammation: Inhibitors of Cox‑2 or Adhesion Molecules Proceedings of a Conference Held on April 15–16, 1996, in New Orleans, USA, Supported by an Educational Grant from Boehringer Ingelheim, ed. Nicolas Bazan, Jack Botting, and John Vane (Dordrecht: Springer Netherlands, 1996).

случайно попробовал кору ивы: Vane and Botting, “History of AntiInflammatory Drugs”. Succeeded in extracting: Alan Jones, “Terminology and Processes Used in Drug Manufacture”, in Chemistry: An Introduction for Medical and Health Sciences (Chichester, UK: John Wiley & Sons, 2005).

работал под руководством своего коллеги: Walter Sneader, “The Discovery of Aspirin: A Reappraisal”, British Medical Journal 321, no. 7276 (Dec. 23–30, 2000).

тысячи американцев умирают от кровотечений: Michael Fine, “Quantifying the Impact of NsaidAssociated Adverse Events”, American Journal of Managed Care 19, no. 14, Suppl. (Nov. 2013).

их называли чудодейственными препаратами: Kay Brune and Burkhard Hinz, “The Discovery and Development of Antiinflammatory Drugs”, Arthritis & Rheumatism 50, no. 8 (2004).

Он назвал этот гипотетический препарат: Frank Heynick, “The Original ‘Magic Bullet’ Is 100 Years Old”, British Journal of Psychiatry 195, no. 5 (2009).

на самом деле является активным процессом: См., например: James N. Fullerton and Derek W. Gilroy, “Resolution of Inflammation: A New Therapeutic Frontier”, Nature Reviews Drug Discovery 15, no. 8 (Aug. 1, 2016); I. Tabas and C. K. Glass, “Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities”, Science 339, no. 6116 (Jan. 11, 2013).